The Scattered State of the Reference Genome

1 · Clay McLeod · Nov. 2, 2019, 9:17 p.m.
Lately, I’ve been intrigued by the variety of reference genomes used across the genomics community. The picture of just how many different versions of the genome exist began to become clear as I researched what reference genome other major projects were using for this RNA-Seq pipeline RFC. I did a moderately comprehensive analysis of these in this Jupyter notebook, but this post serves as a short commentary on what I found, why I think it matters, and what the takeaways are moving forward.The co...