Cloudflare has announced the general availability of Python Workers on their server-side platform after a two-year preview. This allows developers to run Python through WebAssembly using Pyodide within Cloudflare’s V8-based runtime. However, multiprocessing and threading are not supported in this environment. The local development tool, pywrangler, simulates this setup effectively. The investment highlights Cloudflare's commitment to enhancing the Python ecosystem.