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You can see the activation of anterior insula and the anterior cingulate cortex, when the brain experience suffering from physical or social. However, there are no localized center of pain, but it spreads to multiple regions. Some study regards the region of the pain as blanketing effect, and takes it to further research concerned with positive emotion. Based on the evidence of acetaminophen, which wipe out either negative feelings and emotional sensitivity, Way and his colleagues did two ...